Nanoscale Stiffness Distribution in Bone Metastasis

• 作者: Catherine Gros Fabien Bornert Florence Fioretti Fran?ois Clauss Laetitia Keller Ludovic Richert Nadia Benkirane-Jessel Philippe Clézardin Quentin Wagner Sophie Bahi William Bacon
• 来源期刊: 纳米科学与工程(英文)
• 学科: 医学
• 关键词: BONE METASTASIS STIFFNESS RISEDRONATE
• 年，卷（期）: 2015,（4）
• 页码范围: 219-228
• 页数: 10页
• 分类号: R73

摘要

Nanomechanical heterogeneity is expected to have an effect on elasticity, injury and bone remodelling. In normal bone, we have two types of cells (osteoclasts and osteoblasts) working together to maintain existing bone. Bone cancers can produce factors that make the osteoclasts work harder. This means that more bone is destroyed than rebuilt, and leads to weakening of the affected bone. We report here the first demonstration of the nanoscale stiffness distribution in bone metastases before and after treatment of animals with the bisphosphonate Risedronate, a drug which is currently used for the treatment of bone metastases in patients with advanced cancers. The strategy used here is applicable to a wide class of biological tissues and may serve as a new reflection for biologically inspired scaffolds technologies.