Cytomegalovirus in human brain tumors:Role in pathogenesis and potential treatment options

• 作者: Cecilia Soderberg-Nauclér John Inge Johnsen
• 来源期刊: 世界实验医学杂志
• 学科: 医学
• 关键词: CYTOMEGALOVIRUS Oncovirus GLIOBLASTOMA MEDULLOBLASTOMA BRAIN tumor
• 年，卷（期）: 2015,（1）
• 页码范围: 1-10
• 页数: 10页
• 分类号: R

摘要

During the last years increasing evidence implies that human cytomegalovirus(CMV)can be attributed to human malignancies arising from numerous tissues.In this perspective,we will review and discuss the potential mechanisms through which CMV infection may contribute to brain tumors by affecting tumor cell initiation,progression and metastasis formation.Recent evidence also suggests that anti-CMV treatment results in impaired tumor growth of CMV positive xenografts in animal models and potentially increased survival in CMV positive glioblastoma patients.Based on these observations and the high tumor promoting capacity of this virus,the classical and novel antiviral therapies against CMV should be revisited as they may represent a great promise for halting tumor progression and lower cancer deaths.