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Objectives: In the last decade gut microbial diversity was associated with the pathogenesis of obesity in humans. Plasma citrulline was a simple and accurate biomarker for the severity of intestinal failure and was associated with short bowel syndrome and alteration of gut permeability, being developed as an alternative to D-xylose tolerance test for the diagnosis of an abnormal small intestinal absorption of nutrients. This study was performed to ascertain whether obesity might be associated with dysregulation of epithelial gut function. Methods: Fifteen obese individuals (5 M/10 F;BMI 37.4 ± 6.1 Kg/m2;42 ± 6 yrs) and 15 healthy gender- and age-matched controls (6 M/9 F BMI: 22.7 ± 2.1 Kg/m2;39 ± 7 yrs) underwent D-xylose load (25 g) and plasma citrulline, plasma insulin, glucose and lipid profile testing. Results: Plasma citrulline was significantly lower in the obese group (p = 0.045) with respect to controls, whilst total cholesterol, LDL and trygliceri- des concentration, insulin level and HOMA-IR were significantly higher in obese patients. In contrast, after D-xylose load no difference in serum xylose was found between the two groups (p = ns). Conclusions: Obese patients show a decreased citrulline concentration with respect to lean subjects. Since citrulline is a known marker of intestinal health, alterations in the gut epithelium are likely to be associated with the obesity syndrome. We propose to measure citrulline level in obese patients on a routine basis.
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篇名 Plasma Citrulline: A New Marker of Gut Epithelium Alteration in Obese Patients?
来源期刊 糖尿病(英文) 学科 医学
关键词 CITRULLINE Obesity HOMA-IR GUT
年,卷(期) 2015,(4) 所属期刊栏目
研究方向 页码范围 233-237
页数 5页 分类号 R5
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CITRULLINE
Obesity
HOMA-IR
GUT
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糖尿病(英文)
季刊
2160-5831
武汉市江夏区汤逊湖北路38号光谷总部空间
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