CD146: the unveiling of a pro-angiogenic netrin receptor
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摘要:
Netrin-1,a classic neuronal guidance cue,can promote angiogenesis under certain developmental and pathological conditions,but key receptors on vascular endothelium have remained elusive.A recent study published in Cell Research by Tu et al.reveals that CD146,an endothelial receptor of the immunoglobulin superfamily,binds netrin-1 with high affinity and may play an important role in regulating angiogenesis.