Benzimidazole derivatives: search for GI-friendly anti-inflammatory analgesic agents

• 作者: Chander Mohan Deepika Uppal Malkeet Singh Bahia Monika Gaba Neelima Dhingra Om Silakari Punam Gaba
• 来源期刊: 药学学报:英文版
• 学科: 医学
• 关键词: NSAIDs
• 年，卷（期）: 2015,（4）
• 页码范围: 337-342
• 页数: 6页
• 分类号: R914.5
• 语种: 中文

摘要

Non-steroidal anti-inflammatory drugs(NSAIDs) have been successfully used for the alleviation of pain and inflammation in the past and continue to be used daily by millions of patients worldwide. However, gastrointestinal(GI) toxicity associated with NSAIDs is an important medical and socioeconomic problem. Local generation of various reactive oxygen species plays a significant role in the formation of gastric ulceration associated with NSAIDs therapy. Co-medication of antioxidants along with NSAIDs has been found to be beneficial in the prevention of GI injury. This paper describes the synthesis and biological evaluation of N-1-(phenylsulfonyl)-2-methylamino-substituted-1H-benzimidazole derivatives as anti-inflammatory analgesic agents with lower GI toxicity. Studies in vitro and in vivo demonstrated that the antioxidant activity of the test compounds decreased GI toxicity.