Solventless Organic Reactive Crystallization at Mild Conditions

• 作者: Hiroyuki Akagaki Masaaki Yokota Norihito Doki
• 来源期刊: 化学工程与科学期刊(英文)
• 学科: 化学
• 关键词: Reaction CRYSTALLIZATION POLYMORPHISM DEHYDRATION CONDENSATION
• 年，卷（期）: 2015,（4）
• 页码范围: 461-464
• 页数: 4页
• 分类号: O6

摘要

Solid state mixtures of two reactants, 2-hydroxy-1-naphthaldehyde and 2-aminobenzonitrile, were melted at a temperature even lower than both the melting points. And dehydration condensation reaction occurred in the melt to give reaction product N-(2-cyanophenyl)-2-hydroxy-1-naphthadimine. Since the melting point of the product was higher than the reactants, self-crystallization of the product occurred. Usefulness of this one-pot synthesis and crystallization method for industrial application was described.