Synthesis and antiviral activity of a series of novel N-phenylbenzamide and N-phenylacetophenone compounds as anti-HCV and anti-EV71 agents

• 作者: Huiqiang Wang Yanping Li Yuhuan Li Zhi Jiang Zhuorong Li Zonggen Peng
• 来源期刊: 药学学报:英文版
• 学科: 医学
• 关键词: synthesis N-phenylbenzamide N-phenylacetophenone Anti-HCV Anti-EV71 Agents
• 年，卷（期）: 2015,（3）
• 页码范围: 201-209
• 页数: 9页
• 分类号: R914.5
• 语种: 中文

摘要

A series of novel N-phenylbenzamide and N-phenylacetophenone compounds were synthesized and evaluated for their antiviral activity against HCV and EV71(strain SZ-98).The biological results showed that three compounds(23,25 and 41) exhibited considerable anti-HCV activity(IC50? 0.57–7.12 μmol/L) and several compounds(23,28,29,30,31 and 42) displayed potent activity against EV71 with the IC50 values lower than 5.00 μmol/L.The potency of compound 23(IC50? 0.57 μmol/L) was superior to that of reported compounds IMB-1f(IC50? 1.90 μmol/L) and IMB-1g(IC50? 1.00 μmol/L) as anti-HCV agents,and compound29 possessed the highest anti-EV71 activity,comparable to the comparator drug pirodavir.The efficacy in vivo and antiviral mechanism of these compounds warrant further investigations.