Aquaporin-dependent excessive intrauterine fluid accumulation is a major contributor in hyper-estrogen induced aberrant embryo implantation

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2015,（1）
• 页码范围: 139-142
• 页数: 4页
• 语种: 中文
• DOI: 10.1038/cr.2014.139

摘要

Dear Editor, In mammalian species,the window of implantation is defined as a limited period when implantation-competent blastocyst can interact with the receptive endometrium [1].Besides the acquisition of blastocyst competency and uterine receptivity,initiation of embryo implantation also involves a timely reabsorption of intrauterine fluids,which facilitates the apposition of embryo with the uterine lining [2].These processes are coordinated by preimplantation ovarian estrogen (E2) and progesterone (P4):a small E2 surge imposed on a P4-primed environment initiates implantation [1],where the level of E2 and ratio of P4/E2 must be kept within an optimal range [3,4].