The Impact of Human Immunodeficiency Virus Infection (HIV) on Lymphoma in South Africa

• 作者: Atul Lakha Dianne Turton Geoff Candy Moosa Patel Sugeshnee Pather Tanvier Omar Vinitha Philip
• 来源期刊: 癌症治疗(英文)
• 学科: 医学
• 关键词: Human IMMUNODEFICIENCY Virus (HIV) NON-HODGKIN LYMPHOMA (NHL) South Africa High Grade ADVERSE Prognostic Factors Poorer Overall Survival
• 年，卷（期）: azzlyw_2015,（6）
• 页码范围: 527-535
• 页数: 9页
• 分类号: R73

摘要

Human immunodeficiency virus (HIV) infection is endemic in South Africa. Non-Hodgkin lymphoma (NHL) occurs with increased frequency in HIV seropositive individuals. The increase in NHL has been more marked in the last decade, with HIV being the major contributor to this increase. More than 70% of the adult NHL patients at Chris Hani Baragwanath Academic Hospital (CHBAH), Soweto, Johannesburg, are HIV seropositive. In addition, HIV has impacted on the clinical presentation—being more aggressive and atypical. Histologically, HIV-NHL typically manifests as B-cell, high grade lymphomas, including diffuse large B-cell lymphoma (DLBCL);Burkitt lymphoma (BL);B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and BL and plasmablastic lymphoma. The latter two entities, which were previously rare or unknown, have gained prominence in the last decade, occurring primarily in HIV seropositive individuals. HIV-NHL, being associated with all these adverse prognostic factors results in a poorer overall survival.