Effect of the Melatonin on Morning Blood Pressure Surge and Norepinephrine Endovenous Infusion in Healthy Volunteers

• 作者: Jaime Carranza-Madrigal José Miguel Cervantes-Alfaro Sonia María López-Correa
• 来源期刊: 临床医学国际期刊(英文)
• 学科: 医学
• 关键词: BLOOD Pressure HYPERTENSION MELATONIN NOREPINEPHRINE Orthostatism
• 年，卷（期）: 2015,（7）
• 页码范围: 458-464
• 页数: 7页
• 分类号: R5

摘要

Melatonin, the pineal gland hormone, has been considered as a central hypotension factor. However their roles in the regulation of the human blood pressure and its possible use as antihyper-tensive drug have not been fully determined. The objective of this trial was to determine the effect of melatonin on blood pressure morning increase and a peripheral vasoconstriction challenge in healthy volunteers. Twelve healthy male volunteers were included in a prospective, comparative, randomized, crossover trial in which changes on blood pressure (BP) and heart rate (HR) after the first morning orthostatism and endovenous norepinephrine (NE) infusion were measured one hour after the administration of placebo (PL) or 10 mg of melatonin in double blind conditions. Melatonin blunted the effects of the first orthostatism on BP and HR. Melatonin also reduces the pressor effect of NA. One concludes that melatonin has central and peripheral hypotensive effects that support a potential role of this hormone in cardiovascular therapeutics.