2,4-Dinitrophenol Downregulates Genes for Diabetes and Fatty Liver in Obese Mice

• 作者: Jiang He Qian Gao Qingping Zeng Tao Liao
• 来源期刊: 生物科学与医学(英文)
• 学科: 医学
• 关键词: Obesity Metabolic Disease LOW-GRADE Inflammation 2 4-Dinitrophenol ANTI-INFLAMMATION
• 年，卷（期）: 2015,（9）
• 页码范围: 44-51
• 页数: 8页
• 分类号: R5

摘要

Whether obesity is a disease or a risk factor of metabolic diseases including type 2 diabetes and fatty liver remains debating, we report here that a high-fat diet (HFD) alone or HFD-combined intramuscular injection with a high dose (1.2 mg/kg) of lipopolysaccharide (LPS) induces mouse peripheral noninflammatory obesity. In contrast, HFD-combined intraperitoneal injection with a low dose (0.25 mg/kg) of LPS induces mouse visceral low-grade inflammatory obesity. While the noninsulin-dependent diabetes mellitus (NIDDM) and nonalcoholic fatty liver disease (NAFLD)- related genes are globally upregulated in HFD + low-dose LPS mice, NIDDM and NAFLD genes are not extensively upregulated in HFD + high-dose LPS mice. The mitochondrial uncoupler 2,4-dini- trophenol (DNP) in the dosage of 16 mg/kg was found to exert a weight-reducing effect in obese mice by compromising NF-κB-primed inflammatory responses, thereby down regulating NIDDM and NAFLD genes. Conclusively, mouse visceral low-grade inflammatory obesity that predisposes NIDDM and NAFLD can be ameliorated by DNP via anti-inflammation.