Nanocarrier-mediated co-delivery of chemotherapeutic drugs and gene agents for cancer treatment

• 作者: Lin Kang Mingji Jin Qiming Wang Wei Huang Zhonggao Gao
• 来源期刊: 药学学报:英文版
• 学科: 医学
• 关键词: Nanocarrier Co-delivery Chemotherapeutic drug Gene Liposome Micelle Dendrimer Supramolecular system
• 年，卷（期）: 2015,（3）
• 页码范围: 169-175
• 页数: 7页
• 分类号: R979.1
• 语种: 中文

摘要

The efficacy of chemotherapeutic drug in cancer treatment is often hampered by drug resistance of tumor cells,which is usually caused by abnormal gene expression.RNA interference mediated by si RNA and mi RNA can selectively knock down the carcinogenic genes by targeting specific m RNAs.Therefore,combining chemotherapeutic drugs with gene agents could be a promising strategy for cancer therapy.Due to poor stability and solubility associated with gene agents and drugs,suitable protective carriers are needed and have been widely researched for the co-delivery.In this review,we summarize the most commonly used nanocarriers for co-delivery of chemotherapeutic drugs and gene agents,as well as the advances in co-delivery systems.