Cdk1: conductor of CENP-A symphony orchestra

• 来源期刊: 科学通报（英文版）
• 年，卷（期）: 2015,（4）
• 页码范围: 486-487
• 页数: 2页
• 语种: 中文
• DOI: 10.1007/s11434-015-0744-9

摘要

The inheritance of human genome through mitosis is precisely regulated by a series of tightly orchestrated events such as chromosome condensation,bi-orientated spindle formation,chromosome congression,segregation and cytokinesis.Chromosome movements during mitosis are governed by dynamic interactions of spindle microtubules with a specialized chromosome domain called centromere.Centromere provides the platform for the assembly of a protein machine named kinetochore that orchestrates accurate interaction between chromosomes and spindle microtubules during cell division.In eukaryotic organisms,the centromere is epigenetically specified by nucleosomes containing a unique histone H3 variant CENP-A,with the exception of budding yeast [1].