Platelet Indices in Patients with Acute Coronary Syndrome

• 作者: Ana Paula Marte Chacra Carmen Guilherme de Matos Vinagre Maria Regina Andrade de Azevedo Silvia Cristina Costa
• 来源期刊: 生物科学与医学(英文)
• 学科: 医学
• 关键词: PLATELETS PLATELET Indices ACUTE CORONARY SYNDROME CK-MB
• 年，卷（期）: 2015,（11）
• 页码范围: 71-76
• 页数: 6页
• 分类号: R5

摘要

The platelet indices Mean Platelet Volume (MPV), Platelet Distribution Width (PDW) and Plate-letcrit (PCT) provided by automated hematology analysis are rarely used in clinical practice. Platelets play a central role in the pathogenesis of acute coronary syndromes (ACS) and high MPV has been associated to more reactive platelets and regarded as an independent risk factor for myocardial infarction. In this study, platelet indices were evaluated in 39 patients with ACS presenting two altered biochemical parameters, C reactive protein (CRP) and creatine kinase fraction MB (CK-MB). The results obtained showed significantly higher MPV and PDW values in the group with ACS in comparison to the control group. Also observed was a weak but significant positive correlation between MPV and CK-MB. In view of findings of previous studies, which have associated macroplatelets with higher thrombotic potential our results suggest that the use of the MPV and PDW indices as additional and complementary markers may contribute to the investigation and follow-up of thrombotic risk in patients with ACS.