Cancer Therapy Using Antibiotics

• 作者: Biplob Bhattacharya Sreya Mukherjee
• 来源期刊: 癌症治疗(英文)
• 学科: 医学
• 关键词: ANTIBIOTICS LACTAMS CANCER MECHANISM of Action
• 年，卷（期）: 2015,（10）
• 页码范围: 849-858
• 页数: 10页
• 分类号: R73

摘要

Anticancer antibiotics have made a successful impact in the field of chemotherapeutics. For most of them, DNA is the molecular target. Some act as DNA intercalators or some prevent DNA repair among other mechanisms of actions, they are seen to have. The major disadvantages of these drugs though are the constant side effects and toxicities. With more focus on discovery of new drugs with newer scaffolds, the urge to discover and modify anticancer antibiotics is being lost. Modifications or even the wider research can yield newer better drugs for clinical use. The review here discusses the current antibiotic therapeutics, newer discoveries in the field as well ideas for future research.