Use of smart designed nanoparticles to impact cancer surgery

• 来源期刊: 科学通报（英文版）
• 年，卷（期）: 2015,（1）
• 页码范围: 142-143
• 页数: 2页
• 语种: 中文
• DOI: 10.1007/s11434-014-0701-z

摘要

Cancer surgery remains the foundation of cancer treatment and one of the most efficient approaches for cancer cure.Typically,the primary goal of cancer surgery is to cure cancer by removing all the cancerous tissues,which is usually achieved by removing the cancer along the surrounding healthy (non-cancerous) tissue to ensure complete cancer deletion,i.e.,mastectomy and lumpectomy in breast cancer surgery as well as lobectomy and pneumonectomy in lung cancer surgery.However,exception does exist.In the case of glioblastoma multiforme (GBM),the surgeons face the dilemma—they want to remove all the "sick" tissue without the luxury to remove tumor adjacent normal tissue (that could play a key functional role).Recently,Kircher group [1] at Memorial Sloan Kettering Cancer Center developed a handheld Raman scanner to intraoperatively identify surfaceenhanced Raman scattering (SERS) nanoparticles that were intravenously (Ⅳ) administrated and preferably accumulated at GBM site.The SERS nanoparticles serve as a detection probe that helps the researchers to accurately identify cancerous cells in brain tumor surgery in a GBM mouse model.