AIM: To examine the discrepancy, if any, between theendoscopist's estimate and pathologist's measurementof colonic polyp size.METHODS: We retrospectively studied 88 patientswho underwent colonoscopy with a clear unequivocaldocumentation of polyp size by both the endoscopist andpathologist. Endoscopist measurements were based onthe visual estimate of polyp size seen on high definitionscreens. The measurement was done by our pathologistsafter formalin fixation. We compared the endoscopistestimate of the polyp size to the pathologist measurementin order to explore the discordancebetween the tworeadings. Data regarding demographics and method ofpolypectomy (snare polypectomy vs excisional biopsy)was collected, as well. Statistical analysis softwarestatistical software was used to analyze the data.RESULTS: Our cohort included 88 patients from which111 polyps were removed. Fifty-two (46.8%) of the111 polyps were excised using biopsy forceps and fiftynine(53.2%) were removed by snare. In the biopsyforceps group, the mean polyp size documented by thepathologist was 0.38 ± 0.19 cm and the mean polypsize documented by the endoscopist was 0.54 ± 0.16 cm. The mean difference was 0.15 cm (P 〈 0.001).In the snare group, the mean polyp size documentedby the pathologist was 0.54 ± 0.24 cm and the meanpolyp size documented by the endoscopist 0.97 ± 0.34cm. The mean difference was 0.42 cm (P 〈 0.001).Combining both groups, the mean size documentedby pathologist was 0.46 ± 0.23 cm compared to 0.76± 0.35 cm documented by the endoscopist. The meandifference was 0.3 cm (95%CI: 0.23-0.36).CONCLUSION: Post polypectomy measurement by thepathologist are generally smaller than the endoscopist'sestimate.