Synthesis, Characterization and Biological Screening of Ferulic Acid Derivatives

• 作者: A. V. S. Madhu Latha B. V. S. Lokesh Ch. Sri Alekhya T. Naga Mounika T. Naga Ravi Kiran Y. Rajendra Prasad
• 来源期刊: 癌症治疗(英文)
• 学科: 医学
• 关键词: Ferulic Acid Cytotoxicity HELA (Cervical CANCER CELL Lines) A549 (Lung CANCER CELL Lines) HT-29 (Colorectal CANCER CELL Lines) SYNTHESIS
• 年，卷（期）: azzlyw_2015,（10）
• 页码范围: 917-931
• 页数: 15页
• 分类号: R73

摘要

According to WHO, cancer is a leading cause of death worldwide, accounting for 8.2 million deaths in 2012. Among several factors involved in the pathogenesis of cancer, free radical formation followed by damage to DNA and cell protein is one of the causes. Natural plant products have gained enormous interest in the prevention or treatment of chronic diseases. Ferulic acid, like other phenolic acids (caffeic acid, sinapic acid) possess anti cancer activity. A series of ferulic esters (FE1 - FE11) and ferulic amides (FA1 - FA10) were synthesized and evaluated for their cytotoxic activity.