Fission yeast telomere-binding protein Taz1 is a functional but not a structural counterpart of human TRF1 and TRF2
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摘要:
Dear Editor,
Telomeres,the natural ends of linear eukaryotic chromosomes,are essential for cell viability and genome integrity [1].In mammalian cells,telomere repeat factors 1 and 2 (TRF1 and TRF2) are the first two identified mammalian telomere-binding proteins that play essential roles in telomere homeostasis and maintenance [2,3].