Change of Erythrocytes Transport Function in Blood of Men with Prostate Adenocarcinoma (before and after Plastic Orchiectomy)

• 作者: Ana Khazaradze Liana Ramishvili Manana Alibegashvili Manana Gordeziani Nanuli Kotrikadze Nato Veshapidze Nino Gabunia Teimuraz Chigogidze
• 来源期刊: 癌症治疗(英文)
• 学科: 医学
• 关键词: PROSTATE TUMORS PLASTIC ORCHIECTOMY Na+/Ka+-ATP-ase
• 年，卷（期）: 2015,（15）
• 页码范围: 1249-1253
• 页数: 5页
• 分类号: R73

摘要

The changes of blood erythrocytes transport function in patients with prostate adenocarcinoma have been studied according to alterations in Na+/K+-ATP-ase activity and permeability of Na+ and K+ ions, before and after the plastic orchiectomy. The results of the study revealed that activity of Na+/K+-ATP-ase was increased compared with the data before the orchiectomy, but this parameter was reduced compared with control group. The increased amounts of the Na+ as well as K+ ions were also observed in the extracellular area compared with the same data before the orchiectomy. The amount of cholesterol, after plastic orchiectomy, was reduced compared with the data gained before orchiectomy, but the data were greater than those of the control group. It may be presumed that one of the reasons for change of Na+/K+-ATP-ase activity is variation of cholesterol content in erythrocyte membrane. Changes of the active transport system, in turn, affect the transport function of the erythrocyte membrane. In spite of surgical intervention, full recovery of patients does not take place after the plastic orchiectomy. Comparative normalization and approaching to the control group of the given indices in post-operation period (~6 months after surgery) indicate strengthening of the immune system and correspondingly—protective abilities of an organism, which was proved by the anamneses of patients.