Plant, environmental conditions and management type will determine final crop yield. Enhanced yield can be reached by using well-adapted and potentially productive genotypes;all of them ally to crop cultural practices and management. Among these, seed density stands out, once it interferes with plant morphology and competition for water and nutrients. Thus, this study aimed to evaluate the effect of varied seed densities on agronomic traits in soybean, besides identifying cultivars with wide adaptability to different environments and seed densities. Six soybean cultivars were assessed under four seed densities (100, 200, 300 and 400 thousand plants·ha-1), in nine different environments from Minas Gerais State, Brazil. The experimental design was a completely randomized block design with three replications. The BRSMG 760SRR and BRSMG 820RR cultivars had the best average performance independent of the environments and seed densities. The seed density of 300 thousand plants per hectare showed to be as the most adequate for soybean cultivation on the evaluated environments. Furthermore, seed density interacted with the agronomic traits in soybean.