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摘要:
Artemisinin, an endoperoxide sesquiterpene lactone has proven effective in treating drug resistant cases of malaria and cancer. Artemisia annua [sweet wormwood] is the sole source for artemisinin production in many countries. To counter the low content in leaves and costly chemical synthesis process in India, alternative ways to produce artemisinin have been sought. In current study, we collected A. pallens, A. japonica and A. nilagirica from Western Ghats of Maharashtra, India and analyzed artemisinin content. Samples were extracted from leaves and florets in various extraction conditions and analyzed using different chromatographic techniques. Thin layer chromatography (TLC) and high performance thin layer chromatography (HPTLC) analysis showed the presence of compound with endoperoxide linkage in A. nilagirica. High performance liquid chromatography (HPLC) analysis showed the detection of artemisinin in methylene dichloride florets extract of A. japonica, but the concentration was too low [1.3 mg/g dry wt.] for further analyses. Gas chromatography/mass spectrometry (GC/MS) analysis identified structurally important components in the A. nilagirica ethyl acetate extract which explores the biosynthetic pathway of artemisinin from its most important precursor amorpha-4,11-diene. This is the first report of chromatographic screening of these Indian varieties of Artemisia spp. for artemisinin content.
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篇名 Screening of Different <i>Artemisia</i>spp. from Western Ghats of Maharashtra for an Anti-Malarial Compound—Artemisinin
来源期刊 美国植物学期刊(英文) 学科 医学
关键词 ARTEMISIA pallens ARTEMISIA nilagirica ARTEMISIA japonica ENDOPEROXIDE Amorpha-4 11-diene
年,卷(期) 2015,(9) 所属期刊栏目
研究方向 页码范围 1619-1632
页数 14页 分类号 R28
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研究主题发展历程
节点文献
ARTEMISIA
pallens
ARTEMISIA
nilagirica
ARTEMISIA
japonica
ENDOPEROXIDE
Amorpha-4
11-diene
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
美国植物学期刊(英文)
月刊
2158-2742
武汉市江夏区汤逊湖北路38号光谷总部空间
出版文献量(篇)
1814
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0
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