目的:探讨股骨近端防旋转髓内钉( PFNA)内固定治疗不稳定股骨粗隆间骨折的临床疗效。方法:选取2012年4月至2014年1月间收治的不稳定型股骨粗隆间骨折患者66例,随机分为观察组与对照组,观察组患者采用PFNA内固定治疗,对照组采用股骨近端解剖型锁定钢板( ALP )内固定治疗,对比两组患者术中、术后情况及骨折愈合时间,并对患者进行1年回访,观察其髋关节功能Harris评分改善情况。结果:观察组患者手术时间、术出血量、术后引流量及下地负重时间均显著优于对照组( P<0.05);术后1年回访,观察组髋关节功能Harris评分优良率为94.7%,对照组为92.9%,两组间比较无统计学差异( P>0.05)。结论:PFNA治疗不稳定股骨粗隆间骨折效果显著,且创伤小、操作简单、固定可靠,患者术后可早期进行功能康复训练,对年龄较大、不能耐受较长时间手术、身体状况较差的患者,应优先考虑使用。groups were compared .Meanwhile , the patients were received a one-year return visit .The situation of Harris hip joint function score improved was observed .Result:The operation time , peri-operative blood loss , post-operative sunction drainage , and the underground load time in the patients of the observation group were sig-nificantly superior to those in the control group ( P<0.05).The postoperative one-year return visit showed that the excellent and good rate of Harris hip joint function score was 94.7%, while that in the control group was 92.9%.There were no significant differences between the two groups ( P>0.05).Conclusion:The effi-cacy of PFNA in treating unstable femoral intertrochanteric fracture patients is obvious .Meanwhile, PFNA has the advantages of little trauma , easy for operating, and a reliable fixation.After operation, the patients can make an early functional rehabilitaion training .To those who are old , unable to endure the long-time op-eration, and have bad physical conditions , PFNA should be adopted in preference .