AIM: To determine the effectiveness of pharmacological and interventional treatment of hypotony and flat anterior chamber(FAC) resulting from glaucoma filtration surgery.·METHODS: We retrospectively examined the medical records of fifty-two trabeculectomy patients(52 eyes)who developed postoperative hypotony and FAC. The management and associated complications of hypotony,changing intraocular pressure(IOP) and best corrected visual acuity(BCVA) were evaluated.·RESULTS: Of the 52 patients with hypotony, 29(56%)had a grade 1 FAC, 21(40%) had a grade 2 FAC, and only 2 had a grade 3 FAC. There was no significant difference between the mean preoperative IOP and the mean IOP at three and six months after surgery. Thirteen eyes(25%) required antiglaucomatous medication three months after surgery. The mean BCVA at 6mo after surgery was significantly reduced as compared with the mean preoperative BCVA.·CONCLUSION: Hypotonia and FAC following trabeculectomy are associated with troublesome complications that require pharmacological and/or surgical treatment. Thus, close follow-up is essential for affected patients.