Diffusion tensor imaging of optic nerve and optic radiation in primary chronic angle-closure glaucoma using 3T magnetic resonance imaging

• 作者: Bai-Chao Ren Dong Wang Qiu-Juan Zhang Xiao-Hui Li Zhi-Lan Bai
• 来源期刊: 国际眼科杂志：英文版
• 学科: 医学
• 关键词: 主要角度闭合绿内障 长期 眼的神经和眼的放射 散开张肌成像 磁性的回声成像
• 年，卷（期）: 2015,（5）
• 页码范围: 975-979
• 页数: 0页
• 分类号: R775

摘要

AIM: To evaluate the value of quantitative diffusion tensor imaging(DTI) in assessing the axonal and myelin damage of the optic nerves and optic radiations in patients with chronic primary angle-closure glaucoma(PACG) by using high-field magnetic resonance(MR)imaging(3T).·METHODS: Twenty patients with bilateral chronic PACG and twenty age- and sex matched disease-free control subjects were enrolled. Conventional MRI and DTI were performed on all subjects using 3T MR scanner.Mean diffusivity(MD), fractional anisotropy(FA), axial diffusivities(AD) and radial diffusivities(RD) of each optic nerve and each optic radiation were measured by using post-processing software of DTI studio 2.3, and then compared between left eyes and right eyes and between patients group and control group. The paired-sample t- test were used.·RESULTS: There was no abnormality in the shape and signal intensity of the optic nerves and optic radiations in patients group and control group on the conventional MRI. No significant differences were observed in the FA,MD, AD and RD between the right and left optic nerves and optic radiations within patients group and control group(P >0.05). The optic nerves and optic radiations of patients with chronic PACG, as compared with control subjects, had significantly higher MD, AD, RD and significantly lower FA(P <0.05).·CONCLUSION: The diffusivity of optic nerves and opticradiations in chronic PACG group showed abnormal and diffusivity parameters could be used markers of axonal and myelin injury in glaucoma.