Brain-derived neurotrophic factor in patients with advanced age-related macular degeneration

• 作者: Alijan Nemati Amir Khosravi Mahyar Malekzadeh Mehrdad Afarid Mohammad Torabi-Nami
• 来源期刊: 国际眼科杂志：英文版
• 学科: 医学
• 关键词: 年龄相关的有斑点的退化 导出大脑的神经营养的因素 浆液水平 致病
• 年，卷（期）: 2015,（5）
• 页码范围: 991-995
• 页数: 0页
• 分类号: R774.5

摘要

AIM: To investigate the serum level of the brain-derived neurotrophic factor(BDNF) in age-related macular degeneration(AMD) and healthy control subjects. The disruption in the tight balance of neuroinflammatory and neuroprotective processes in an immune-privileged site like retina is proposed to contribute to the pathogenesis of AMD. One of the main neuroprotective mediators in the central nervous system is BDNF with its serum level notably affected in several neurodegenerative disorders.·METHODS: Thirty-six patients with AMD and 36 agematched controls were enrolled in this study. The serum level of BDNF was measured using the enzyme-linked immunosorbent assay method. Results were analyzed to compare case and control values. Comparisons were also made between the BDNF level of wetvs dry-AMD,and male vs female patients and controls. Analysis of variance(ANOVA) and Student’s t-test were employed to analyze the data.·RESULTS: The mean BDNF levels in AMD group were significantly higher than the control group. Furthermore,our analysis revealed greater BDNF values in all AMDsubgroups compared to controls(P =0.004, 0.005, 0.001 and 0.02 for male wet-AMD, male dry-AMD, female wetAMD and female dry-AMD vs controls, respectively). The BDNF level however did not vary between wet- and dryAMD patients(P =0.74). While within-group comparisons in males and females of AMD and control groups did not show any difference in BDNF(P =0.16, 0.64 and 0.85 for wet-AMD, dry-AMD and control groups, respectively),between-group data showed a higher mean BDNF in both male and female AMD subjects than their peer controls.·CONCLUSION: This study demonstrated that the serum BDNF level is different in patients with AMD as compared to subjects without AMD. Future attempts should be done to unravel beneficial or deleterious effect of this neurotrophin in the pathogenesis of AMD.