Measurement of macular pigment optical density among healthy Chinese people and patients with early-stage age-related macular degeneration

• 作者: Hong Gu Jun Xu Jun-Yan Zhang Ning-Li Wang Ning-Pu Liu Torkel Snellingen Xi-Pu Liu Xiu-Fen Yang Xu Han Xue Li Xue-Tao Ren
• 来源期刊: 国际眼科杂志：英文版
• 学科: 医学
• 关键词: 年龄相关的有斑点的退化 食谱 foveal 建筑学 有斑点的颜料光密度
• 年，卷（期）: 2015,（6）
• 页码范围: 1190-1195
• 页数: 0页
• 分类号: R774.5

摘要

AIM: To measure the macular pigment optical density(MPOD) in healthy Chinese people and patients with early age-related macular degeneration(AMD).·METHODS: Cross-sectional population based study.Demographic and lifestyle characteristics were ascertained by questionnaire. A food frequency questionnaire was completed for all participants.Participants underwent general physical and ophthalmic examinations and MPOD was measured by heterochromatic flicker photometry. Foveal architecture was measured by optical coherence tomography.·RESULTS: MPOD of 225 participants(122 healthy and 103 early AMD) was 0.48 ±0.18. Patients with early AMD(0.52 ±0.19) tended to have higher MPOD levels than healthy people(0.47 ±0.17), but the difference was not statistically significant(P =0.06). Participants with carrot or corn oil intake every week tended to have higher levels of MPOD(P =0.002 and 0.008 respectively) while those with corn intake had relatively lower level of MPOD(P =0.01). MPOD increased with the center foveal thickness(P =0.01).· CONCLUSION: Our findings show that there is no statistically significant association between MPOD and early AMD in the studied population. MPOD is related to center foveal thickness and diets would influence MPOD levels.