Comparison of intravitreal bevacizumab with intravitreal triamcinolone acetonide for treatment of cystoid macular edema secondary to retinal vein occlusion : a Meta-analysis

• 作者: Yan Sun Yi Qu
• 来源期刊: 国际眼科杂志：英文版
• 学科: 医学
• 关键词: BEVACIZUMAB 网膜的静脉吸藏 元分析 triamcinolone acetonide
• 年，卷（期）: 2015,（6）
• 页码范围: 1234-1239
• 页数: 0页
• 分类号: R774.1

摘要

AIM: To compare the effects of intravitreal injection of bevacizumab(IVB) with intravitreal triamcinolone acetonide(IVTA) on the treatment of cystoid macular edema(CME) secondary to retinal vein occlusion(RVO).·METHODS: A literature search was conducted using Pub Med, the Cochrane Central Register of Controlled Trials, Web of Science and the Chinese Biomedical Database. The comparison was divided into two groups,group 1 conducted comparison in branch RVO(BRVO) or central RVO(CRVO), group 2 conducted comparison in ischemic-RVO or nonischemic-RVO. Pooled mean differences(MDs) for changes in visual acuity(VA),central macular thickness(CMT) and intraocular pressure(IOP) were calculated in groups at 4, 12 and 24 wk after treatment respectively.·RESULTS: Eight studies comparing the efficacy of IVB with IVTA were included in the Meta-analysis. In group 1,in BRVO, significant difference was shown on the comparison of CMT at 24wk(MD,-45.66; 95% CI,-76.03to-15.28; P =0.003), IVB was effective on BRVO for at least 24wk; no significant differences were found in the comparison of VA at each time points(P >0.05respectively). In CRVO, no significant differences were found in the comparison of VA or CMT between IVB and IVTA at each time points(P >0.05, respectively). In group2, in ischemic-RVO, significant differences were shown in the comparison of VA(MD,-0.28; 95% CI,-0.42 to-0.14;P <0.0001) and CMT(MD,-86.50; 95% CI,-151.18 to-22.43;P =0.008) at 24wk; In nonischemic-RVO, no significant differences were demonstrated in the comparison of VA or CMT between IVB and IVTA at each time points(P >0.05, respectively). The occurrence of high IOP was much lower in IVB group.·CONCLUSION: This Meta-analysis suggested that IVB was effective in decreasing CMT in BRVO for at least24 wk, IVB is more effective on improving VA and reducing CMT in ischemic-RVO. IVB is more promising on RVO than IVTA.