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摘要:
The objective of this study was to characterize and verify the in vitro antitumor activity of essential oils (EOs) extracted from the leaves and flowers of Callistemon viminalis. The EOs were extracted by hydrodistillation using a modified Clevenger apparatus. The identification and quantification of constituents were performed on a gas chromatograph coupled to a mass spectrometer and a gas chromatograph with a flame ionization detector. The antitumoral activity was evaluated by a colorimetric assay (MTS) using different cell lines derived from human tumors (breast, lung, glioblastoma, and melanoma). The major constituents of the EOs of leaves and flowers were similar, only quantitative differences being observed. The compounds 1,8-cineole, α-pinene and α-terpineol were found in concentrations of 50.4%, 25.8% and 8.7% in the EOs obtained from the leaves and 48.8%, 24.5% and 3.9% in the EOs obtained from the flowers, respectively. The cytotoxic activity of the EOs was observed only in melanoma cultures (HT144). Cultures treated for 48 h with EOs from leaves and flowers (200 μg·mL-1) reduced the viability by 40% and 25%, respectively. Thus, the antiproliferative activity of the EO from leaves was more pronounced than the EO from flowers in cells derived from melanoma.
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篇名 Chemical Characterization and in Vitro Antitumor Activity of the Essential Oils from the Leaves and Flowers of Callistemon viminalis
来源期刊 美国植物学期刊(英文) 学科 医学
关键词 Cancer VOLATILE OIL Escova-de-Garrafa (Bottle Brush)
年,卷(期) 2015,(16) 所属期刊栏目
研究方向 页码范围 2664-2671
页数 8页 分类号 R73
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Cancer
VOLATILE
OIL
Escova-de-Garrafa
(Bottle
Brush)
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美国植物学期刊(英文)
月刊
2158-2742
武汉市江夏区汤逊湖北路38号光谷总部空间
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1814
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