Correlation between thoracic aorta 18F-natrium fluoride uptake and cardiovascular risk

• 作者: Alberto Nieri Arnoldo Piccardo Cecilia Marini Francesco Fiz Gianmario Sambuceti Giulia Ferrarazzo Manlio Cabria Marco Canepa Matteo Bauckneht Nathan Artom Silvia Morbelli
• 来源期刊: 世界放射学杂志：英文版（电子版）
• 学科: 医学
• 关键词: POSITRON emission tomography/computed tomography 18F-Natrium fluoride PLAQUE imaging Cardiovascular risk profile THORACIC AORTA
• 年，卷（期）: 2016,（1）
• 页码范围: 82-89
• 页数: 8页
• 分类号: R54

摘要

AIM: To investigating the relationship between thoracic and cardiac 18F-Natrium-Fluoride(18F-Na F) uptake,as a marker of ongoing calcification and cardiovascular risk factors.METHODS: Seventy-eight patients(44 females,mean age 63,range 44-83) underwent whole body 18F-Na F positron emission tomography/computed tomography. Cardiovascular risk(CVR) was used to divide these patients in three categories: Low(LR),medium(MR) and high risk(HR). 18F-Na F uptake was measured by manually drawing volumes of interest on the ascendingaorta,on the aortic arch,on the descending aorta and on the myocardium; average standardized uptake value was normalized for blood-pool,to obtain target-tobackground ratio(TBR). Values from the three aortic segments were then averaged to obtain an index of the whole thoracic aorta.RESULTS: A significant difference in whole thoracic aorta TBR was detected between HR and LR(1.84 ± 0.76 vs 1.07 ± 0.3,P < 0.001),but also between MR and HR-LR(1.4 ± 0.4,P < 0.02 and P < 0.01,respectively). Significance of this TBR stratification strongly varied among thoracic aorta subsegments and the lowest P values were reached in the descending aorta(P < 0.01). Myocardial uptake provided an effective CVR classes stratification(P < 0.001).Correlation between TBR and CVR was appreciable when the whole thoracic aorta was considered(R = 0.67),but it peaked when correlating the descending thoracic segment(R = 0.75),in comparison with the aortic arch and the ascending segment(R = 0.55 and 0.53,respectively). CONCLUSION: Fluoride uptake within the thoracic aorta wall effectively depicts patients’ risk class and correlates with cardiovascular risk. Descending aorta is the most effective in CVR determination.