Gastrointestinal endoscopy is the gold standard in the examination and the treatment of the diseases of gastrointestinal system,but the disadvantage of being painful process.At this point the sedative and analgesic agents may be important.Dexmedetomidine is a new sedoanalgesic agent which is alternative to benzodiazepines and opioids.It has analgesia,amnesia,sedative and anxiolytic properties.The use of dexmedetomidine as the sole anesthetic agent and as the adjuvant analgesic agent has been published but has not been approved because of the inconsistency of efficacy and safety.The author has been collected the published papers in the literature.This article is aimed to describe the use of dexmedetomidine in various gastrointestinal endoscopic procedures.