Retrospective study of a cohort of adult patients with hematological malignancies in a tropical area

• 作者: Béatrice Cenciu Florin Santa Jean-Pierre Droz Jérome Fayette Laure Bianco Maia Forgues Pierre Couppié
• 来源期刊: 世界血液学杂志
• 学科: 医学
• 关键词: Tropical hematology Multiple myeloma NON-HODGKIN LYMPHOMAS CHRONIC lymphoid LEUKEMIA Adult T-cell-lymphoma-leukemia Hodgkin disease CHRONIC myeloid LEUKEMIA Acute LEUKEMIA HUMAN T-lymphotropic VIRUS 1 HUMAN immunodeficiency VIRUS
• 年，卷（期）: 2016,（1）
• 页码范围: 37-50
• 页数: 14页
• 分类号: R

摘要

AIM:To review the characteristics of hematological malignancies in tropical areas,and to focus on the specific difficulties regarding their management.METHODS:This is a retrospective narrative review of cases of patients with hematological malignancies.All medical files of patients with malignant disease whose treatment was coordinated by the Hemato-Oncology service of the Cayenne Hospital in French Guiana between the 1st of January 2010 and the 31st of December 2012 were reviewed.Clinical data were extracted from the medical files and included:Demographic data,comorbidities,serological status for human immunodeficiency virus,human T-lymphotropic virus 1(HTLV1),hepatitis B virus and hepatitis C virus infections,cytology and pathology diagnoses,disease extension,treatment,organization of disease management,and follow-up.The subgroup of patients with hematological malignancies and virus-related malignancies were reviewed.Cases involving patients with Kaposi sarcoma,and information on solid tumor occurrence in virus-infected patients in the whole patient population were included.Since the data were rendered anonymous,no informed consent was obtained from the patients for this retrospective analysis.Data were compiled using EXCEL?software,and the data presentation is descriptive only.The references search was guided by the nature of the data and discussion.RESULTS:In total,the clinical files of 594 patients(pts)were reviewed.Hematological malignancies were observed in 87 patients,and Kaposi sarcoma in 2 patients.In total,70 patients had a viral infection,and 34 of these also had hematological malignancies.The hematological diagnoses were:Multiple myeloma in 27 pts,lymphoma(L)in 43 pts,myeloproliferative disorders in 17 pts and Kaposi sarcoma in two patients.The spectrum of non-Hodgkin lymphomas(NHL)was:Burkitt L(1 pt),follicular L(5 pts),chronic lymphocytic leukemia(5 pts),high-grade NHL(9 pts),mucosa-associated lymphoid tissue NHL(4 pts),T-cell lymphoma(4 pts),Adult T-cell lymphoma-leukemia(ATL)/lymphoma/leukemia(12