Development of regional specificity of spinal and medullary dorsal horn neurons

• 作者: Barry J Sessle Xian-Min Yu Xing-Hong Jiang Yu-Feng Xie
• 来源期刊: 世界生物化学杂志：英文版（电子版）
• 学科: 医学
• 关键词: REGIONALIZATION DEVELOPMENT Central nervous system TRIGEMINAL subnucleus caudalis SPINAL CORD Pain
• 年，卷（期）: 2016,（1）
• 页码范围: 138-145
• 页数: 8页
• 分类号: R338

摘要

Extensive studies have focused on the development and regionalization of neurons in the central nervous system(CNS). Many genes, which play crucial roles in the development of CNS neurons, have been identified. By using the technique 'direct reprogramming', neurons can be produced from multiple cell sources such as fibroblasts. However, understanding the region-specific regulation of neurons in the CNS is still one of the biggest challenges in the research field of neuroscience. Neurons located in the trigeminal subnucleus caudalis(Vc) and in the spinal dorsal horn(SDH) play crucial roles in pain and sensorimotor functions in the orofacial and other somatic body regions, respectively. Anatomically, Vc represents the most caudal component of the trigeminal system, and is contiguous with SDH. This review is focused on recent data dealing with the regional specificity involved in the development of neurons in Vc and SDH.