Mycosis fungoides and Sèzary syndrome are the most common subtypes of cutaneous T-cell lymphomas.Even though,in early-stage disease,Mycosis fungoides commonly has a more indolent course,disease will progress in about 20%of such patients.About 30%of patients have been reported to develop advancedstage disease and,at present,there is no cure for the disease.A number of systemic approaches have been used for advanced-stage mycosis fungoides(IIB-IV)and transformed disease.Aggressive approaches seem to be warranted in such patients.The scope of this review is the stem cell transplantation in mycosis fungoides and its leukemic variant,Sèzary syndrome.