Cell-based therapy in Alzheimer’s disease: Current knowledge and perspective

• 作者: Hongyun Huang Lin Chen Liyan Qiao
• 来源期刊: 临床转化神经医学(英文版)
• 学科: 医学
• 关键词: Alzheimer’s DISEASE cell THERAPY STEM cells NEUROGENESIS
• 年，卷（期）: 2016,（1）
• 页码范围: 50-58
• 页数: 9页
• 分类号: R749.16

摘要

Alzheimer’s disease(AD)is the most prevalent type of dementia,and its neuropathology is characterized by the deposition of insolubleβ‐amyloid(Aβ)peptides,intracellular neurofibrillary tangles,amyloid angiopathy,age‐related brain atrophy,synaptic pathology,white matter rarefaction,granulovacuolar degeneration,neuron loss,and neuroinflammation.Although much is known about the neurobiology of AD,very few conventional therapies are available to arrest or slow the disease.There is an urgent need for novel therapeutic approaches for AD.AD subjects have significantly fewer viable precursor cells in the hippocampus compared with age‐matched healthy control subjects.However,the viable precursor cells that remain in AD and age‐matched healthy control brain specimens can be induced to differentiate.To facilitate or mimic the natural compensatory effect in AD,cell therapy,including endogenous and exogenous stem cells,has been considered in AD.In this review,we focus on the history and development of cell therapy in AD,and consider the role of cell therapy as a potential treatment for AD.