Diagnostic and therapeutic biomarkers in pancreaticobiliarymalignancy

• 作者: Domenico Viterbo Tamas Gonda Valerie Gausman
• 来源期刊: 世界胃肠内镜杂志：英文版（电子版）
• 学科: 医学
• 关键词: Biological markers Pancreatic cancer CHOLANGIOCARCINOMA DIAGNOSTIC PROGNOSTIC Predictive BRUSH specimens BIOPSIES
• 年，卷（期）: 2016,（3）
• 页码范围: 128-142
• 页数: 15页
• 分类号: R

摘要

Pancreatic ductal adenocarcinoma （PDAC） and cholangiocarcinoma（CCA） are two malignancies that carry significantmorbidity and mortality. The poor prognoses ofthese cancers are strongly related to lack of effectivescreening modalities as well as few therapeutic options.In this review, we highlight novel biomarkers that havethe potential to be used as diagnostic, prognostic andpredictive markers. The focus of this review is biomarkersthat can be evaluated on endoscopically-obtained biopsiesor brush specimens in the pre-operative setting.We also provide an overview of novel serum basedmarkers in the early diagnosis of both PDAC and CCA. Inpancreatic cancer, the emphasis is placed on prognosticand theranostic markers, whereas in CCA the utilityof molecular markers in diagnosis and prognosis arehighlighted.