Pathogenicity of a currently circulating Chinese variant pseudorabies virus in pigs

• 作者: Fei-Fei Tan Juan Wang Ke-Gong Tian Li-Lin Wang Ling-Hua Guo Qing-Yuan Yang Xiang-Dong Li Yan Xiao Yu-Zhou Wang Zhe Sun Zhi-Yan Wang
• 来源期刊: 世界病毒学杂志
• 学科: 医学
• 关键词: PSEUDORABIES VIRUS PATHOGENICITY VIRUS VARIANT GROSS pathology HISTOPATHOLOGY
• 年，卷（期）: 2016,（1）
• 页码范围: 23-30
• 页数: 8页
• 分类号: R

摘要

AIM:To test the pathogenicity of pseudorabies virus(PRV)variant HN1201 and compare its pathogenicity with a classical PRV Fa strain.METHODS:The pathogenicity of the newly-emerging PRV variant HN1201 was evaluated by different inoculating routes,virus loads,and ages of pigs.The classical PRV Fa strain was then used to compare with HN1201 to determine pathogenicity.Clinical symptoms after virus infection were recorded daily and average daily body weight was used to measure the growth performance of pigs.At necropsy,gross pathology and histopathology were used to evaluate the severity of tissue damage caused by virus infection.RESULTS:The results showed that the efficient infection method of RPV HN1201 was via intranasal inoculation at 107 TCID50,and that the virus has high pathogenicity to 35-to 127-d old pigs.Compared with Fa strain,pigs infected with HN1201 showed more severe clinical symptoms and pathological lesions.Immunochemistry results revealed HN1201 had more abundant antigen distribution in extensive organs.CONCLUSION:All of the above results suggest that PRV variant HN1201 was more pathogenic to pigs than the classical Fa strain.