Genetically humanized pigs exclusively expressing human insulin are generated through custom endonuclease-mediated seamless engineering

• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2016,（2）
• 页码范围: 174-177
• 页数: 4页
• 语种: 中文
• DOI: 10.1093/jmcb/mjw008

摘要

Dear Editor, Type 1 diabetes (r1D) is a lifelong (chronic)disease and a major health problem throughout the world.This disease can be treated by either insulin injection or islet transplantation.Islet transplantation is considered as a better treatment for T1 D patients,because islets can produce and release insulin at the appropriate time,resulting in tight blood glucose control.However,islet transplantation is performed only for brittle T1D patients due to lack of sufficient donors:only 1 of 333 patients with insulin-dependent diabetes mellitus (IDDM) can obtain human islets (Frank et al.,2005).Porcine insulin has been applied to treat T1D.Recently,pig islets have also proved to be an attractive alternative resource for solving the donor shortage issue for islet transplantation.