Molecularly targeted therapy for advanced hepatocellularcarcinoma - a drug development crisis？

• 来源期刊: 世界胃肠肿瘤学杂志：英文版（电子版）
• 学科: 医学
• 关键词: PANCREATIC cancer NEOADJUVANT Radiationtherapy REVIEW RADIATION TECHNIQUES
• 年，卷（期）: 2016,（2）
• 页码范围: 186-197
• 页数: 12页
• 分类号: R

摘要

This review summarizes the current status of neoadjuvantradiation approaches in the treatment of pancreatic cancer,including a description of modern radiation techniques,and an overview on the literature regarding neoadjuvantradio- or radiochemotherapeutic strategies both forresectable and irresectable pancreatic cancer. Neoadjuvantchemoradiation for locally-advanced, primarily non- orborderline resectable pancreas cancer results in secondaryresectability in a substantial proportion of patients withconsecutively markedly improved overall prognosisand should be considered as possible alternative inpretreatment multidisciplinary evaluations. In resectablepancreatic cancer, outstanding results in terms ofresponse, local control and overall survival have beenobserved with neoadjuvant radio- or radiochemotherapy inseveral phase Ⅰ/Ⅱ trials, which justify further evaluationof this strategy. Further investigation of neoadjuvantchemoradiation strategies should be performed preferentiallyin randomized trials in order to improvecomparability of the current results with other treatmentmodalities. This should include the evaluation of optimalsequencing with newer and more potent systemicinduction therapy approaches. Advances in patientselection based on new molecular markers might be ofcrucial interest in this context. Finally modern externalbeam radiation techniques （intensity-modulated radiationtherapy, image-guided radiation therapy and stereotacticbody radiation therapy）, new radiation qualities （protons,heavy ions） or combinations with alternative boostingtechniques widen the therapeutic window and contributeto the reduction of toxicity.