Long noncoding RNA MALAT1-derived mascRNA is involved in cardiovascular innate immunity

• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2016,（2）
• 页码范围: 178-181
• 页数: 4页
• 语种: 中文
• DOI: 10.1093/jmcb/mjw003

摘要

Dear Editor, Next-generation sequencing revealed that the majority of the human genome is transcribed but has no coding function.It is estimated that ＞30000 long noncoding RNAs (IncRNAs) are expressed in humans,but their functions are largely unknown (Suckau et al.,2009;Rinn and Chang,2012;Poller et al.,2013).Consideration of noncoding genomic elements in pathogenetic studies is warranted and enabled by technological advances allowing comprehensive transcriptome mapping of protein-coding genes as well as small and long ncRNAs.We searched for IncRNAs influencing antiviral capacity in patients with Coxsackievirus B3(CVB3) cardiomyopathy (Kuhl et al.,2012)and assign here immunoregulatory functions to the lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1)and its enzymatic processing product MALAT1-associated small cytoplasmic RNA (mascRNA).