Impaired regulatory T cell function in autoimmune diseases: are microRNAs the culprits?

• 来源期刊: 中国免疫学杂志（英文版）
• 年，卷（期）: 2016,（2）
• 页码范围: 135-137
• 页数: 3页
• 语种: 中文
• DOI: 10.1038/cmi.2015.98

摘要

MicroRNAs (miRNAs) are evolutionarily conserved small non-coding RNA sequences,approximately 22 nucleotides in length,that act as negative regulators of target genes via binding to the 3'-untranslated region of mRNAs,leading to mRNA degradation or the inhibition of mRNA translation.In animal cells,the biogenesis of miRNAs begins in the nucleus with the transcription of double-stranded pri-miRNA (1-3 kb) and ends as a single-stranded ‘mature miRNA’ in the cytoplasm.Drosha and Dicer are the key enzymes that play critical roles in miRNA biogenesis.1,2 miRNA regulates various cellular and physiological processes,and the dysregulated expression of miRNA has been linked to several pathologies,including autoimmune diseases.