Preparation of UO2 microspheres is the basic work for ceramic fuel.Many workers had paid attention on it.In 1970s and 1980s,United States Department of Energy had conducted numerous studies on the fabrication of nuclear fuels particles with the internal gelation process[1].Manufacture nuclear kernels with internal gelation process is the mature method in wet chemical.Internal gelation process has the advantages of high uniform and spherical microspheres can be prepared.In the fabrication process,there are many factors,such as subsequent ageing,HMTA/uranium mole ratio,gelation forming temperature,washing step,heating rate of the calcined and sinter steps,that affect the quality of the microsphere.