Characterization of MT-2 cells as a human regulatory T cell-like cell line

• 来源期刊: 中国免疫学杂志（英文版）
• 年，卷（期）: 2016,（1）
• 页码范围: 132-134
• 页数: 3页
• 语种: 中文
• DOI: 10.1038/cmi.2014.123

摘要

The paucity of naturally occurring CD4+FoxP3+ regulatory T cells (Tregs) and difficulties in the identification and isolation of such cells are major obstacles in the study of human Tregs.The availability of human Treg-like cell lines is likely to facilitate a better understanding of the molecular basis of Treg function and aid the discovery of pharmacological reagents to regulate Treg activity in a disease state.In this study, we examined the Treg phenotype and the immune suppressive effect of a human T-cell leukemia virus type 1 (HTLV-1) infected cell line, MT-2.The results clearly demonstrated that the MT-2 cell line has the phenotypic and functional characteristics of human Tregs and is a useful tool in the study of human Tregs.