Mechanisms underlying 18F-fluorodeoxyglucose accumulation in colorectal cancer

• 作者: Kenji Kawada Masayoshi Iwamoto Yoshiharu Sakai
• 来源期刊: 世界放射学杂志：英文版（电子版）
• 学科: 医学
• 关键词: ¹⁸> F-fluorodeoxyglucose-positron 排放断层摄影术 Colorectal 癌症 葡萄糖新陈代谢 Mutational 地位 KRAS
• 年，卷（期）: 2016,（11）
• 页码范围: 880-886
• 页数: 7页
• 分类号: R735.34

摘要

Positron emission tomography（PET） with 18F-fluorodeoxyglucose（FDG） is a diagnostic tool to evaluate metabolic activity by measuring accumulation of FDG, an analogue of glucose, and has been widely used for detecting small tumors, monitoring treatment response and predicting patients’ prognosis in a variety of cancers. However, the molecular mechanism of FDG accumulation into tumors remains to be investigated. It is well-known that most cancers are metabolically active with elevated glucose metabolism, a phenomenon known as the Warburg effect. The underlying mechanisms for elevated glucose metabolism in cancer tissues are complex. Recent reports have indicated the potential of FDG-PET/CT scans in predicting mutational status（e.g., KRAS gene mutation） of colorectal cancer（CRC）, which suggests that FDG-PET/CT scans may play a key role in determining therapeutic strategies by non-invasively predicting treatment response to anti-epidermal growth factor receptor（EGFR） therapy. In this review, we summarize the current findings investigating the molecular mechanism of 18F-FDG accumulation in CRC.