Value of serial magnetic resonance imaging in the assessment of brain metastases volume control during stereotactic radiosurgery

• 作者: Adele Taibbi Andrea Anastasi Aurelia Banco Francesco Agnello Francesco Bencivinni Gianvincenzo Sparacia Giovanna Giordano Massimo Galia Tommaso Vincenzo Bartolotta
• 来源期刊: 世界放射学杂志：英文版（电子版）
• 学科: 医学
• 关键词: 大脑转移 Stereotactic 镭外科学 磁性的回声成像 伪前进 放射治疗
• 年，卷（期）: 2016,（12）
• 页码范围: 916-921
• 页数: 0页
• 分类号: R73

摘要

AIM To evaluate brain metastases volume control capabilities of stereotactic radiosurgery(SRS) through serial magnetic resonance(MR) imaging follow-up. METHODS MR examinations of 54 brain metastases in 31 patients before and after SRS were reviewed. Patients were included in this study if they had a pre-treatment MR examination and serial follow-up MR examinations at 6 wk, 9 wk, 12 wk, and 12 mo after SRS. The metastasis volume change was categorized at each follow-up as increased(> 20% of the initial volume), stable(± 20% of the initial volume) or decreased(< 20% of the initial volume). RESULTS A local tumor control with a significant(P < 0.05) volume decrease was observed in 25 metastases at 6-wk follow-up. Not significant volume change was observed in 23 metastases and a significant volume increase was observed in 6 metastases. At 9-wk followup, 15 out of 25 metastases that decreased in size at 6 wk had a transient tumor volume increase, followed by tumor regression at 12 wk. At 12-wk follow-up there was a significant reduction in volume in 45 metastases, and a significant volume increase in 4 metastases. At 12-mo follow-up, 19 metastases increased significantly in size(up to 41% of the initial volume). Volume tumor reduction was correlated to histopathologic subtype.CONCLUSION SRS provided an effective local brain metastases volume control that was demonstrated at follow-up MR imaging.