Presenting mitochondrial antigens: PINK1, Parkin and MDVs steal the show

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2016,（11）
• 页码范围: 1180-1181
• 页数: 2页
• 语种: 中文
• DOI: 10.1038/cr.2016.104

摘要

In a recent paper published in Cell,Matheoud et al.demonstrated that,in response to cellular stress,self-antigens can be extracted from mitochondria via mitochondrial-derived vesicles and presented at the cell surface to trigger an immune response;this pathway,termed mitochondrial antigen presentation (MitAP),is repressed by PINK1 and Parkin.These findings implicate autoimmune mechanisms in Parkinson's disease.