Ever HRD a ubiquitin-gated channel?

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2016,（10）
• 页码范围: 1075-1076
• 页数: 2页
• 语种: 中文
• DOI: 10.1038/cr.2016.92

摘要

Elimination of misfolded proteins of the endoplasmic reticulum (ER) requires their retrotranslocation from the ER to the cytosol via membranebound ubiquitin ligase complexes.Baldridge and Rapoport now reconstitute a key step of retrotranslocation,demonstrating a protein conduit gated by ubiquitination.