A CRISPR evolutionary arms race: structural insights into viral anti-CRISPR/Cas responses

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2016,（10）
• 页码范围: 1165-1168
• 页数: 4页
• 语种: 中文
• DOI: 10.1038/cr.2016.103

摘要

Dear Editor, CRISPR/Cas systems are widespread RNA-mediated prokaryotic adaptive immune systems providing protection against invading nucleic acids [1].However,throughout evolution,this host defense system has not resulted in the eradication of phages,suggesting that phages have evolved counter strategies to thrive within bacteria despite these mechanisms [2].Thus,both bacterial CRISPR system and phage anti-CRISPR system are part of a continuing evolutionary battle between bacterial host and their bacteriophage invaders.