Pathway mining-based integration of critical enzyme parts for de novo biosynthesis of steviolglycosides sweetener in Escherichia coil

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2016,（2）
• 页码范围: 258-261
• 页数: 4页
• 语种: 中文
• DOI: 10.1038/cr.2015.111

摘要

Dear Editor, The development of microbial synthetic biology has been revolutionizing the industrial production of important plant terpenoids since the dawn of the century [1,2].By reconstructing the downstream biosynthetic pathways and systematically engineering the supply of common terpenoid precursors,the engineered microorganism chassis (e.g.,Escherichia coli and Saccharomyces cerevisiae) can produce desired terpenoids in a more controllable manner.This strategy is also adapted to enrich the knowledge of cell metabolism via either discovery of novel or proof of postulated pathways [3].