Synchrotron-based heavy-ion accelerator operates in pulse mode at a low repetition rate that is comparable to the patient’s breathing rate[1].To overcome inefficiencies and interplay effects between the target residual motion and the scanned heavy-ion beam delivery process for conventional free breathing-based(FB)gating therapy[2,3],a novel respiratory guidance method was developed to help patients synchronize their breathing patterns with the synchrotron excitation patterns by performing short breath holds(BH)with the aid of personalized audio-visual biofeedback(BFB)system[4].